M. marinum granulomas in zebrafish are well organized and histologically highly similar to Mtb granulomas, with their necrotic centres surrounded by infected macrophages, epithelial cells and infiltrating CD4+ cells and neutrophils (Yoon et al., 2015; Yang et al., 2012; Swaim et al., 2006; van der Sar et al., 2004). This evidence concerns the gene CD4 and Granuloma.