The FGFR1 gene on chromosome 8p11.23 has emerged as a recurrently altered oncogene in a diverse spectrum of primary glial and glioneuronal tumor entities including DNT [31, 33, 34, 40, 41], RGNT [14, 19, 22, 36], EVN [38], pilocytic astrocytoma [3, 18, 27, 34, 44], high-grade astrocytoma with piloid features [2, 32], and H3 K27M-mutant diffuse midline glioma [24]. Here, FGFR1 is linked to astrocytoma (excluding glioblastoma).