One of the three unclassifiable LGNET with FGFR1 p.K656E mutation harbored an accompanying PIK3R1 p.K567E missense mutation, which is a specific variant that has been recurrently found in gliomas and other tumor types [Catalog of Somatic Mutations in Cancer database v91 release]. The gene discussed is FGFR1; the disease is glioma.