BRAF and rosette-forming glioneuronal tumor of fourth ventricule: This underlying pathogenesis of RGNT is different than other low-grade glioneuronal tumors such as ganglioglioma and pilocytic astrocytoma that typically involve a solitary pathogenic alteration (e.g. BRAF mutation or fusion) causing activation of the MAP kinase signaling in isolation [18, 29, 34, 44].