Through combining histologic, genomic, and epigenetic profiling on a series of 30 LGNET with FGFR1 alterations, we have identified that some tumor entities (RGNT and EVN) have a distinct pattern of genetic alterations, while other tumor entities (pilocytic astrocytoma and DNT) have overlapping/indistinct patterns precluding accurate classification based solely on genetic aberrations (Fig. 8). Here, FGFR1 is linked to pilocytic astrocytoma.