In line with the role of NLRC5 in immune response, the target CpGs of NLRC5 were enriched for CpGs that were previously associated with immune-related disorders (including auto-immune disorders primary Sjögren’s syndrome and mixed connective tissue disease and sTNFR2 levels; Additional file 13: Table S13) [32]. The gene discussed is NLRC5; the disease is mixed connective tissue disease.