Additionally, phosphorylation of LDHA at Y10 mediated by human epidermal growth factor receptor 2 (HER2) and avian sarcoma viral oncogene v-src homolog (Src) enhances the formation of LDHA tetramers, increases its activity, and provides an anti-anoikis, pro-invasive, and pro-metastatic potential to cancer cells [34]. This evidence concerns the gene ERBB2 and cancer.