CDKN2A and neoplasm: EZH2 is a catalytic component of the polycomb repressive complex 2 (PRC2), which uses its HMT activity to catalyze the trimethylation of lysine at position 27 of histone H3, resulting in the suppression of downstream tumor suppressor genes such as E-cadherin, P16 INK4α, P57, and PSP94 [30].