ACSL4 and hepatocellular carcinoma: The effect of ACSL4 in the progression of HCC was then explored by transfection of two siRNAs specific for ACSL4 (siACSL4-1 and siACSL4-2) and the ACSL4 overexpression plasmid pcDNA3.1-ACSL4 (ACSL4 OE) into LM3 and SK Hep-1 cells.