GRM5 and Huntington disease: To further validate our findings, we assessed REST/NRSF and SNAP-25 mRNA levels in the bacterial artificial chromosome (BAC) HD mouse (BACHD) model, which was previously shown to exhibit a progressive neurodegenerative phenotype [33, 34], in the absence (BACHD/mGluR5−/−) and presence of mGluR5 (BACHD).