PIK3CA and malignant colon neoplasm: Finally, we exhibited the top 10 mutated genes in colon cancer with ranked percentages, including TTN (47%), APC (75%), MUC16 (27%), SYNE1 (29%), TP53 (55%), KRAS (43%), FAT4 (23%), RYR2 (21%), PIK3CA (28%) and ZFHX4 (21%) (Fig. 7i).