There was no significant difference between the TNF-α titers in normotensive samples from GFAP-IκKβ or IκKβf/f mice (P > 0.05); however, ocular hypertension-induced production of this cytokine was significantly lower in ocular hypertensive GFAP-IκKβ than ocular hypertensive IκKβf/f controls. Here, GFAP is linked to ocular hypertension.