Among the studied cytokines that are known to be transcriptional targets for NF-κB, interleukins (IL), including IL-1A (P < 0.001), IL-1B (P < 0.001), IL-2 (P = 0.01), IL-6 (P < 0.001), IL-10 (P = 0.03), IL-12 (P = 0.04), IL-13 (P = 0.02), interferon-gamma (IFN-γ) (P < 0.001), and TNF-α (P < 0.001) exhibited significantly lower titers in ocular hypertensive retinas of GFAP-IκKβ mice compared to ocular hypertensive IκKβf/f controls. This evidence concerns the gene IL1B and ocular hypertension.