In light of current knowledge, we question whether decreased microglial response to ocular hypertension in GFAP-IκKβ mice might be related to a NF-κB-regulated cross-talk between astroglia and microglia during neuroinflammation and neurodegeneration, and/or might be secondary to decreased neuron injury in these transgenic animals. The gene discussed is NFKB1; the disease is ocular hypertension.