NFKB1 and glaucoma: In addition to NF-κB-regulated immunoreceptors (such as MHC molecules [59] or RAGE [60] that are upregulated on glaucomatous astroglia), other NF-κB targets known to be involved in antigen presentation may also play a critical role in astroglia-mediated activation of systemic immunity in glaucoma [1, 4].