Tissue immunolabeling supported increased production of this pro-inflammatory cytokine in GFAP-labeled astroglia in ocular hypertensive eyes; however, the ocular hypertension-induced TNF-α immunolabeling was prominently decreased in GFAP-IκKβ retinas compared to ocular hypertensive IκKβf/f controls. The gene discussed is TNF; the disease is ocular hypertension.