Based on recent molecular profiling and histopathological analysis of human donor eyes with glaucoma [6] and animal models [7], astroglial nuclear factor-kappaB (NF-κB) seems to be critical for the transcriptional regulation of neuroinflammation that involves cytokine signaling, toll-like receptor (TLR) signaling, and inflammasome activation [6–8]. Here, NFKB1 is linked to glaucoma.