CXCL8 and acute promyelocytic leukemia: In contrast, at the seventh day of treatment with ATRA, we observed that APL plasma samples in non-DS group exhibited significant decreased IL-8 levels (34.16; 6.99 to 147.11 pg mL− 1 in D0 vs. 10.9; 0 to 26.81 pg mL− 1 in D7; p = 0.02 - Fig. 1b; Table 1; Supplementary file 1).