In addition, in contrast to the previous report, showing an relationship between high IL-8 serum levels and the occurrence of DS in two patients with APL [15], our data demonstrate that patients who develop or not the DS may persist with detectable low plasma concentrations of IL-8 after the first week of treatment, suggesting that the modulation of IL-8 levels in patients with APL following ATRA treatment may occur regardless of the DS development. The gene discussed is CXCL8; the disease is Dravet syndrome.