For example, we discovered significant enrichment for several general and prostate cancer transcription factor binding sites (Supplemental Fig. 3), including BRD4 (e = 329), CTCF (e = 254), FOXA1 (e = 188), MYC (e = 181), and AR (e = 159), as well as a microRNA involved in angiogenesis (mir-126) [27, 30] (ReMap; http://tagc.univ-mrs.fr/remap/). The gene discussed is CTCF; the disease is prostate cancer.