CBLN1 and obesity due to melanocortin 4 receptor deficiency: In the experimental model of HFD-induced obesity, we observed a significant intensification of the de novo ceramide synthesis pathway, which resulted in an elevation of intramuscular content of SFA (+21.2%, p < 0.05; Figure 1A), SFA1P (+231.1%, p < 0.05; Figure 1B), CER (+25.7%, p < 0.05; Figure 1C), and SFO (+14.8%, p < 0.05; Figure 1D) after the HFD course in comparison with the control group.