IDH2 and myelodysplastic syndrome: Molenaar et al. explored IDH1/IDH2 mutations in 868 low-risk and 536 high-risk MDS and observed: A higher frequency of IDH1/IDH2 mutations in high-risk than in low-risk MDS, with a similar frequency of IDH1 and IDH2 mutations in low-risk MDS, but a higher proportion of IDH2 than IDH1 mutations in high-risk MDS; variant allelic frequencies indicated that IDH2 mutations are more frequently ancestral than IDH1 mutations; the presence of IDH1/IDH2 mutations was associated with poor overall survival, particularly in low-risk MDS [17].