In the majority of cases, IDH1 or IDH2 mutations were observed both in originary AML and in t-MN or only in t-MN, but not in originary AML; only in one patient, an IDH1 mutation was observed in the originary AML, t-MN, and was persistent at remission [82]. The gene discussed is IDH2; the disease is acute myeloid leukemia.