Silva et al. have explored the mutational profile of elderly AML patients and reported the occurrence of IDH1 mutations (mostly associated with DNMT3A mutations) in about 17% of cases and of IDH2 mutations (mostly associated with DNMT3A and SRSF2 mutations) in about 11% of cases [50]. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.