Recently, Vosberg et al. reported a detailed DNA methylation profiling study in AML patients, focusing on the analysis of the effects of mutations in commonly mutated genes (such as NPM1, FLT3-ITD, DNMT3A, IDH1, IDH2, TET2, and WT1) on DNA methylation profiles and differential gene expression [119]. The gene discussed is IDH1; the disease is acute myeloid leukemia.