Thus, Wihle et al. have shown that myeloid leukemia cells overexpressing mutant IDH or that have been cultured in the presence of R-2-HG and TET2-mutated AML cells did not show similar methylation changes; the methylation patterns were compared to those observed in myeloid progenitor cells [92]. The gene discussed is IDH2; the disease is acute myeloid leukemia.