TP53 and acute myeloid leukemia: Lindsley et al. reported a detailed analysis of the mutational profiling of 101 t-AMLs: T-AMLs resulted in being a heterogeneous disease that, according to the genetic ontogenic-based classification, can be subdivided into three subgroups: 30% with a s-AML pattern; 23% with a TP53-mutated pattern; 47% with de novo-AML-mutated pattern.