IDH2 and acute myeloid leukemia: This model was used to understand some molecular changes associated with evolution towards IDH2 independence and to identify some vulnerabilities of IDH2-independent AML, showing that: (i) An increase in reactive oxygen species (ROS) may cause a genotoxic effect; (ii) enrichment of the tretinoin/retinoic acid pathway; (iii) suppression of LSD1 demethylase; (iv) upregulation of Pin1 prolyl isomerase [108].