BCL2 and acute myeloid leukemia: IDH1- and IDH2-mutant primary human primary human AML cells were more sensitive than IDH1/IDH2-WT AML cells to ABT-199, a specific BCL-2 inhibitor [110]; this sensitization of mutant IDH AML cells is induced by R-2-HG-mediated inhibition of the activity of cytochrome c oxidase in the mitochondrial electron transport chain [110].