IDH1 and brain neoplasm: Recently, the identification of a new potent, mutant-selective IDH1 inhibitor FT-2102 (Olutasidenib) was reported: This inhibitor is highly active in mutant IDH1 xenotransplantation mouse models, orally bioavailable, with excellent pharmacokinetic properties, and is a promising candidate for treatment of hematologic, solid, and brain tumors [149].