The study of 140 t-AML patients showed IDH1/IDH2 mutations in 7% MDS and 12% of t-AML: Less frequently with IDH1 (3/12 cases of IDH-mutated tumors) and more frequently with IDH2 mutations (9/12 cases IDH-mutated) [78]. The gene discussed is IDH1; the disease is myelodysplastic syndrome.