The most frequently mutated genes in these patients were ASXL1, TET2, SRSF2, U2AF1, RUNX1, and TP53. IDH1 and IDH2 genes were mutated in 7% and 10% of cases, respectively and this frequency did not change after progression to AML [62]. Here, SRSF2 is linked to acute myeloid leukemia.