IDH1 and acute myeloid leukemia: As a consequence of these defects, IDH-mutant AML cells are sensitive to PARP inhibitors as monotherapy, but particularly when combined with a DNA-damaging agent, such as daunorubicin; in contrast, concomitant administration of IDH1/IDH2 inhibitors during cytotoxic therapy decreases the efficacy of PARP inhibitors or of daunorubicin [156].