An extensive analysis of functional and topographic effects on DNA methylation in various IDH1-IDH2 mutant cancers, including AML, showed that in addition to the previously described DNA hypermethylation phenotype, IDH1-IDH2 mutant tumors display also a high level of DNA hypomethylation, which is particularly relevant at the level of gene promoters [120]. The gene discussed is IDH1; the disease is cancer.