NPM1 and acute myeloid leukemia: IDH1 and IDH2 are recurrently mutated in some AML subtypes (Table 1) mainly represented by NPM1-mutated, RUNX1-mutated AMLs, and AMLs bearing MLL-partial tandem duplication (MLL-PTD) and trisomy of chromosome 11 [36,40,41,42,43,44,45,46,47,48].