It is of interest to note that studies of mutational profiling carried out in primary myelofibrosis have shown the occurrence of SRSF2 mutation in 17% of cases; SRSF2 mutations were frequently associated with IDH mutations: In SRSF2-mutated PMFs, 13% displayed IDH1 mutations, compared to 1% in SRSF2 wild-type PMFs; in SRSF2-mutated PMFs, 16% displayed IDH2 mutations compared to 2% in SRSF2 wild-type PMFs [73]. This evidence concerns the gene IDH1 and myelofibrosis.