NPM1 and acute myeloid leukemia: In fact, according to this study based on the genomic characterization of 1540 AML adult patients, while IDH2-R172-mutant AMLs are mainly clustered in a distinct subgroup exhibiting a co-mutation pattern limited to DNMT3A mutations, both IDH1-mutant and IDH2-R140-mutant AMLs are scattered in different AML subgroups, including NPM1-mutated, chromatin-spliceosome-mutated, and not-classified AMLs.