No significant interaction between plasma desmosines and peripheral or total arterial calcification mass was found (p = 0.63 for interaction plasma desmosines and peripheral arterial calcification, p = 0.57 for interaction plasma desmosine and total arterial calcification mass) (Table 3), which shows that both elastin degradation and arterial calcification mass independently contribute to lowering ABI in PXE. This evidence concerns the gene ELN and Pseudoxanthoma elasticum.