As shown in Figure 6A, the cytotoxicity of SM3GRNLY was the same as that of GRNLY alone on A549 and MCF-7 cells, that is, cell lines that did not show a substantial binding of SM3GRNLY in the flow cytometry experiments shown in Figure 5A. However, the SM3GRNLY immunotoxin exhibited a higher cytotoxicity than granulysin alone on H929 multiple myeloma cells, reducing the IC50 from 10 to 2.5 μM (Figure 6B, lower panel). Here, GNLY is linked to AL amyloidosis.