Impressively, crocin demonstrated the pro-apoptotic activity in chemosensitive OV2008 and chemoresistant C13 cervical cancer cells through an increased level of BAX and p53 and a decreased level of Bcl-2 and miR-365 that is an upstream regulator of both BAX and Bcl-2; however, slightly better pro-apoptotic effect of crocin was observed in OV2008 sensitive cells. The gene discussed is BCL2; the disease is cervical carcinoma.