Furthermore, fucoxanthin activated apoptosis via inhibition of PI3K/Akt/mTOR pathway in U87 and U251 human glioma cancer cells [151] and induced apoptosis in adenocarcinoma SGC-7901 or BGC-823 human gastric cells involving downregulation of Mcl-1, STAT3 and p-STAT3 [152]. This evidence concerns the gene STAT3 and adenocarcinoma.