Therefore, the OCT LAR induced reduction of Tregs ENTPD1 positive, which we reported in our study, results in less functional Tregs, and may restore the Teff and NK cells anti-tumour response, as well as allow the accumulation of ATP at the tumour site that will trigger the recruitment of DCs, monocytes and macrophages at the tumour site. The gene discussed is ENTPD1; the disease is neoplasm.