No significant correlation was detected between the peripheral Tregs basal value and their OCT LAR induced decrease and metastasis site (hepatic vs. other sites) and number, Ki67 (Ki67 < 5 vs. Ki67 > 5), grading of tumour (G1 vs. G2), size of the tumour and functional status (functional vs. non-functional), suggesting that, although Tregs decrease may represent the OCT LAR benefit, this is not enough to impact on known prognostic factors. Here, MKI67 is linked to neoplasm.