In the acute myeloblastic leukemia with maturation (M2) subtype of acute myeloid leukemia (AML), the in-flame fusion protein AML1-ETO (AE) isoform AE9a, a transcription factor, interacts with PRMT1 and recruits it to the AE9a promoter. The gene discussed is RUNX1; the disease is acute myeloid leukemia.