The import of 90% of the net amino acid demand is mediated directly or indirectly by SNAT1 (SLC38A1) and SNAT2 (SLC38A2), because they are the main neutral amino acid loaders in cancer cells and provide exchange substrates for antiporters to capture amino acids not transported by SNAT1 and SNAT2 (Figure 2). The gene discussed is SLC38A1; the disease is cancer.