MTOR and familial dilated cardiomyopathy: Identification of TTNtv in DCM is helpful for prognosis; however, as targeted therapies for TTNtv become available, this may also change clinical management (Table 1).Given the association of TTNtv inducing upregulation of the mTOR complex, mTOR inhibitors such as rapamycin may be reasonable to consider for therapeutic trials of TTNtv DCM [52].