LEP and obesity due to melanocortin 4 receptor deficiency: Obesity is accompanied by an alteration of the adipokine profile (changes in the serum levels of adiponectin, leptin, resistin, chemerin, omentin, apelin, adipsin, vaspin, visfatin), as well as by the presence of inflammation (evidenced by changes in the adhesion molecules sICAM1—soluble Intercellular Adhesion Molecule 1 and sVCAM1—soluble Vascular Adhesion Molecule 1) [5,14].