It remains to be investigated whether compounds 22 and 40 may interact with estrogen receptors, since these compounds have structural similarity with isoflavones (such as daidzein and genistein) and to some degree with tamoxifen, which have been used for the treatment of oral squamous cell carcinoma that express estrogen receptors [65,66,67]. Here, ESR1 is linked to oral cavity squamous cell carcinoma.