Cdc42 was found to be upregulated in the prefrontal cortex of schizophrenic patients [131] and several other Rho effectors have been reported to be associated with schizophrenia, such as Kalirin, known as ArhGEF24, ArhGEF11, ArhGAP18, ArhGAP33, Myosin lXb, and Chimerin 2 [15,132,133]. This evidence concerns the gene KALRN and schizophrenia.