AGT and chronic kidney disease: MAFbx/Atrogin-1 and MuRF-1 are shown to be increased in various muscle atrophy-inducing conditions, including disuse, denervation, inflammation, aging, glucocorticoid increase, high Ang II, and chronic diseases such as cancer, congestive heart failure, chronic kidney disease, chronic obstructive pulmonary disease (COPD), and AIDS [31,32].