TLR4 and Sepsis: Platelets abundantly express surface TLR4 [77,87,95,97,104,105] (Figure 2 and Table S2), and platelet-TLR expression has also been shown to increase in patients with ACS [14,16], sepsis [12], community-acquired pneumonia [106] and is modulated during Crohn’s disease during the acute and remission stages [107].