After exposure to cancer targets, though the percentage of cells expressing TIM-3 stayed the same, the median fluorescence intensity (MFI) for TIM-3 decreased significantly, by 2926 and 2620 Intensity Units, for 2.5:1 and 10:1 effector(E): target (T) ratios, respectively (Figure 1A). This evidence concerns the gene HAVCR2 and cancer.