The association between high TIM-3 expression and the downregulation of genes including MEOX1, CAPN6, PRAC1 and CXCL17 in GBM suggests the role of this receptor may not be fully inhibitory, owing to the pro-tumorigenic roles that have been described for these genes [44,45,46,47,48]. The gene discussed is MEOX1; the disease is glioblastoma.