Interestingly, among the most highly downregulated genes in TIM-3+ GBM samples included MEOX1 (mesenchyme homeobox 1), CAPN6 (calpain 6), PRAC1 (prostate cancer susceptibility candidate protein 1) and CXCL17. These genes carry out various distinct roles, but have also been associated with the capacity to exert pro-tumorigenic functions in a number of cancers. The gene discussed is CAPN6; the disease is cancer.