CHCHD10 and amyotrophic lateral sclerosis: Whilst mutations of CHCHD10 display a mitochondrial disease that resembles motor neuron disease, a large consortium of motor neuron disease (amyotrophic lateral sclerosis) patients (n = 4365) and healthy controls (n = 1832) from seven countries subsequently demonstrated that pathogenic CHCHD10 variants are exceptionally rare [252].