Despite significant improvement of treatment strategies in the last decade, owing both to the emergence of BRAF- or MEK-targeted therapies and checkpoint blockade immunotherapies (i.e., anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and anti-programmed cell death-1 (PD-1)), the prognosis for patients with metastatic melanoma remains uncertain, predominantly due to treatment failures and recurrences [2]. The gene discussed is MAP2K7; the disease is metastatic melanoma.