A role for miR-137 as a tumor suppressor is evident: overexpression of miR-137 was reported to decrease the expression of CDK6, suggesting that miR-137 acts through the inhibition of CDK6 in lung cancer cells, while the decreases in miR-137 expression in tumor cells support the role of miR-137 in the pathogenesis of cancer, including pancreatic cancer, 109 osteosarcoma cancers, 110 gastric cancers, 48 oral cancers, and 50 ovarian cancers [24]. Here, CDK6 is linked to familial pancreatic carcinoma.