Finally, we also explored TCGA and Genomics Evidence Neoplasia Information Exchange (GENIE) datasets to check for tumor samples harboring both genetic alterations in one of our candidate genes and NF1. Due to lack of samples or to the higher mutational and clinical heterogeneity, we managed to make reasonable assumptions only for AKT1, VCP, and SDC2. More details are presented in the discussion section. The gene discussed is AKT1; the disease is neoplasm.