UCP2 inhibition by genipin (55) promotes an increase in ROS, triggers the nuclear translocation of glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH), formation of autophagosomes and expression of LC3-II autophagy marker, leading to cell death or growth inhibition, invasion and migration of tumor cells. This evidence concerns the gene GAPDH and neoplasm.