GPT and Decreased total leukocyte count: In the acute study, 14 days after administration, leukopenia and hemosiderin accumulation were observed in the spleen, and in the subacute, after 30 days, changes in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and total proteins were observed, indicating hepatotoxicity and nephrotoxicity for the dose of 100 mg/kg, in addition to leukopenia and renal hemorrhage [115].