Zhao et al. [157] analyzed the protective role of genipin (55) against ischemia-reperfusion lesion associated with energy deficiency and oxidative stress, which are regulated by mitochondrial uncoupling protein 2 (UCP2) and NAD-dependent deacetylase sirtuin-3 (SIRT3), respectively. Here, UCP2 is linked to hyperinsulinemic hypoglycemia, familial, 4.