CASP3 and cancer: This promotes cytochrome c release for caspase-3 activation and increases pro-apoptotic protein expression, which leads to cancer cell apoptosis when tested against MKN-28 and A-549 cells with IC50 of 2.5 and 5.6 μM and HepG2 cancer cells with IC50 of 21.72 μM, respectively [28,29].