Invadopodia revealed multiple core neoplastic roles associated with cancer malignancy; for example, invasiveness requires actin-regulating proteins, such as actin-related proteins 2/3 (Arp2/3), cortactin, Wiskott–Aldrich syndrome protein-interacting protein (WIP), and proteolysis; these signals are required for metallopeptidase-2/metallopeptidase-9 (MMP-2/MMP-9) and membrane Type 1-matrix metalloproteinase (MT1-MMP) to degrade the ECM in the metastasis process [18,20]. This evidence concerns the gene ACTR2 and cancer.