NOS3 and hypertensive disorder: This effect is comparable to that observed by Kobayashi et al. [33] who described that increased expression of Ace and Nos3 genes following administration of imidapril to rats with hypertension induced by L-NAME; authors described that it could be attributed to a change in different systems responsible for regulating BP, as a compensatory response to the synthesis of ACE and the uptake of Ang-II by the receivers.