TBK1 and diffuse large B-cell lymphoma: In order to determine the effects of IKKε/TBK1 inhibition on DLBCL cell line growth, we used DMX3433 (Figure 2A), an IKKε/TBK1 inhibitor with pIC50 for the purified enzymes of 7.8 for IKKε and 7.9 for TBK1, which was available in sufficient quantities for all cellular and in vivo studies.