Collectively, our work showed effects of inhibitors on RELA phosphorylation and gene expression, which supports a role for IKKε/TBK1 in contributing to NF‐κB activity in some DLBCL and we note that Ly10, which was used for the gene expression studies has constitutive NF‐κB activity due to MYD88 mutation. Here, MYD88 is linked to diffuse large B-cell lymphoma.