IKBKB-DT and neoplasm: To determine the relationship between ALAL-1 expression and the level of tumor infiltration by immune populations, TCGA LUSC samples were grouped in six subgroups ranging from low to high presence of cytotoxic cells based on the enrichment of gene signatures of specific immune cell populations (Tamborero et al., 2018; Fig. 7 A), and ALAL-1 expression in each of these subgroups was assessed.