CD4 and neoplasm: In concordance with changes in the composition of secreted factors, the enforced expression of ALAL-1 resulted in decreased migration toward the tumor cells of several immune cell populations, such as CD8+, CD3+, and CD4+ lymphocytes, natural killer cells, and monocytes (Fig. 7 E), confirming an inhibitory effect of ALAL-1 in their capacity to chemo-attract cells.