Next, to explore the relationship between ALAL-1 and specific subtypes of immune cells in lung adenocarcinomas, we classified TCGA LUAD tumors based on the amplification state of the ALAL-1 gene and determined the enrichment of cell type–specific gene signatures (Hänzelmann et al., 2013; Tamborero et al., 2018). This evidence concerns the gene IKBKB-DT and lung adenocarcinoma.