We analyzed the DNA methylation of the ALAL-1 locus in lung cancer (Sandoval et al., 2013) and found two differentially methylated CpGs mapping to the 5′ end of ALAL-1 (both cg26394282, P value = 1.89e−24 in LUAD and cg16230352, P value = 3.05e−19 in LUSC; Fig. 2, F–H), suggesting that hypomethylation of the ALAL-1 gene in tumors could explain the observed higher level of the lncRNA in those tumors that do not present amplification of the locus. This evidence concerns the gene IKBKB-DT and lung cancer.