Two molecules, methyltransferase‐like protein 3 (METTL3) and insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1), were found to play crucial roles in potentiating resistance to CDDP through m6A methylation of transcription factor‐activating enhancer‐binding protein 2C (TFAP2C) in seminoma. This evidence concerns the gene IGF2BP1 and seminoma.