MAPT and Alzheimer disease: Reduced cerebral blood flow could, in turn, exacerbate aspects of AD progression and independently contribute to cognitive impairment through, for example, acceleration of Aβ aggregation and plaque growth [48], causing white matter deficits in a tau mouse model [44], attenuating interstitial fluid flow [48], and a general cellular adaption to dysregulated blood flow, including pericytes dysfunction [47], metabolic rate contributions [49], and causing cortical atrophy [44].