The KCNNs are involved in various cancers: low KCNN3 expression promotes drug resistance and may predict a poor prognosis in ovarian cancer [27], high KCNN4 expression is associated with poor survival in pancreatic cancer patients [28], and KCNN2 is overexpressed in proximal tumors compared to distal tumors in colorectal cancer [29]. This evidence concerns the gene KCNN4 and cancer.