HIF1A and cancer: GSEA revealed that high expression levels of the 5 genes were significantly enriched in the KEGG pathways related to hypoxia and the development of tumors, including the HIF-1 signaling pathway, PI3K-AKT signaling pathway, MAPK signaling pathway, mTOR signaling pathway, pathways in cancer, apoptosis, and the cell cycle (Figure 6C, 6F, 6I, 6L, 6O).