GDF15, TNFR1, Fas, and MIP1α were selected from a large set of analytes because they have been shown, along with the SASP proteins osteopontin, Activin A, and interleukin 15, to be predictive of adverse health events and had not previously been evaluated as constituents of the cytokine mileu affected by menopausal HT (Miller et al., 2015; Raz et al., 2014, 2016; Schafer et al., 2020). Here, SPP1 is linked to hematocrit.