As noted below, in C.  elegans (Depuydt et al., 2013; Duhon & Johnson, 1995; Herndon et al., 2002) and in Drosophila (Demontis & Perrimon, 2010; Owusu‐Ansah, Song, & Perrimon, 2013), genetic reduction in the insulin/IGF1 signaling pathway, which causes increased nuclear translocation of DAF‐16 (FOXO in mammals), results in lifespan extension and reduced sarcopenia in these organisms. The gene discussed is INS; the disease is sarcopenia.