We found that thecyclin D1, CDK and CDK6 levels were significantly decreased in miR-4490mimic-treated GC cells compared with NC-treated cells, whereas the level ofcyclin B1 remained unchanged (Fig. 2e).These results indicate that overexpression of miR-4490 inhibits the growth of GCcells. The gene discussed is CDK6; the disease is gastric cancer.