PLG and psychotic disorder: These arise from common pathways or functionally interact with coagulation proteins plasminogen and vitamin K–dependent protein S, supporting hypotheses of coagulation activation in psychosis.57 In both the initial and replication experiments, the most highly weighted predictor of transition was A2M (decreased in CHR-T vs CHR-NT), a protease inhibitor with diverse functions, including inhibition of proinflammatory cytokines such as interleukin 1β58 (consistently elevated in FEP59).