PLG and multiple sclerosis: This finding is intriguing given the evidence that blood-derived plasminogen is associated with brain inflammation61 and complement activation.62 In models of multiple sclerosis, blood-brain barrier disruption facilitates transfer of fibrinogen into the brain, where it is deposited as fibrin, causing local inflammation.63 Given evidence for blood-brain barrier disruption in psychosis,64 fibrin may be associated with etiopathogenic mechanisms providing novel therapeutic avenues,65 but this hypothesis requires further investigation.