Also, regarding the frequency of rs4939827 polymorphism of SMAD-7 gene and its genotypes in women patients with breast cancer and healthy women, it was found that the codominant hereditary models (OR=1.71, 95%CI=1.10-2.70, p=0.023) in comparison with TT (OR=2.22, 95%CI=1.20-4.26, p=0.017), CC in comparison with TT and dominant (OR=1.80, 95%CI=1.17-2.76, p=0.009, CT+CC in comparison with TT) and allele C (OR=1.44, 95%CI=1.08-1.89, P-value=0.013, allele C in comparison with allele T) were significantly related to the risk of developing breast cancer. The gene discussed is SMAD7; the disease is breast carcinoma.