Therefore, according to the effects of fucoidan in the up-regulation of Bax, cleaved caspase-3, and cleaved PARP, down-regulation of Bcl-2 and alteration of ΔΨm, it could be implied that fucoidan has potential in apoptotic induction via an intrinsic pathway on HSC-3 oral squamous cell carcinoma. Here, BAX is linked to oral cavity squamous cell carcinoma.