Expression of TFAP2B was elevated in samples from papillary thyroid carcinoma more than samples from adjacent non-neoplastic thyroid tissue of the same patients (p=0.002). TFAP2B expression in papillary thyroid cancer tissues is positively associated with advanced stage, lymph nodes metastases (p=0.003), huge tumor size (p=0.022), presence of extra-thyroid invasion (p=0.005), multifocality of the tumor (p=0.002), vascular invasion (p=0.028), capsular invasion (p=0.004) and distant metastases (p=0.002) (Table 1 and Figure 1-3). The gene discussed is TFAP2B; the disease is neoplasm.