MKI67 and astrocytic tumor: Enduring with the aforementioned role of WT1 in regulating cell proliferation and apoptosis, we found highly significant associations between WT1 score and both Bcl2 and Ki67 indices in grade IV astrocytic tumors, reflecting the aggressive nature and poor prognosis of glioblastomas (Ritchie et al., 2011; Camacho-Urkaray et al., 2018; Tsuboi et al., 2019).