Taken together, we can confirm that WT1 correlates with old age and IDH1 negativity in grade IV astrocytomas indicating a poor outcome and that, absent/low WT1 expression in high-grade astrocytic tumors is associated with younger age and presence of IDH1 mutation (Rauscher et al., 2014), signifying a favorable prognosis for the latter group (Manocha and Jain, 2019). The gene discussed is IDH1; the disease is astrocytic tumor.