Studies on glioma cell lines have shown that WT1 silencing with anti-WT1-shRNA (short hairpin RNA) induces apoptosis through upregulation of apoptosis genes as p53 and PIK3CA (Clark et al., 2010; Kijima et al., 2014; Kijima et al., 2016; Ramsawhook et al., 2018). Here, PIK3CA is linked to central nervous system cancer.