In spite of being low-grade tumors, an unexpectedly higher WT1 expression (either in frequency or score) was described in pilocytic astrocytomas and SEGA as compared to grade II diffuse astrocytomas in different studies (Hashiba et al., 2007; Schittenhelm et al., 2008; Schittenhelm et al., 2009; Mahzouni and Meghdadi, 2012; Manocha and Jain, 2019). This evidence concerns the gene WT1 and pilocytic astrocytoma.