For emphasis, diffuse (grade II/III) astrocytomas, and secondary glioblastoma share a cell of origin that carry IDH mutation (Cai et al., 2016), while IDH-wild glioblastoma may originate from a bipotential precursor cell, a more primordial neural stem cell or even a dedifferentiated transformed astrocyte (Cohen et al., 2013; Louis et al., 2016). Here, IDH1 is linked to astrocytoma (excluding glioblastoma).