The first epigenetic study showed DNA hypermethylation of a BRCA1 promoter in TNBC (Dobrovic et al., 1997) and its frequency varies from 10 to 85% with higher DNA methylation usually found in more invasive breast tumors (Birgisdottir et al., 2006 ; Southey, 2011). This evidence concerns the gene BRCA1 and breast neoplasm.