The independent prognostic factors for RFS, according to the multivariate analysis, were CRP/Alb ratio >0.089 [hazard ratio (HR), 3.00; 95% confidence interval (CI), 1.58–5.69; p <0.001]; lymph node metastasis (HR, 2.64; 95% CI, 1.32–5.30; p = 0.006); and multiple tumors (HR, 3.34; 95% CI, 1.69–6.61; p <0.001). This evidence concerns the gene CRP and metastatic malignant neoplasm in the lymph nodes.